← All peptidesLongevityOnce-daily intramuscular protocol for prostate tissue research.
Prostamax is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Pro, KEDP) derived from prostate tissue peptide complex research. Short peptides of this class have been studied for their ability to modulate gene expression through epigenetic interactions with chromatin and histones. This educational protocol presents a once-daily intramuscular approach.
Get Prostamax → code PROFITProtocol Overview
Concise summary of the regimen.
GoalSupport prostate tissue health research through bioregulatory peptide signaling.
ScheduleDaily intramuscular injections for 8 to 12 weeks (extend to 16 weeks if desired).
Dose Range500 mcg to 1 mg daily with gradual titration.
Reconstitution2.0 mL per 20 mg vial (10 mg/mL).
StorageLyophilized refrigerated or frozen; reconstituted refrigerated; use within 2 weeks.
Dosing & Reconstitution
| WEEK | DAILY DOSE | UNITS PER INJECTION |
|---|
| Weeks 1 to 2 | 500 mcg | 5 units (0.05 mL) |
| Weeks 3 to 4 | 750 mcg | 7.5 units (0.075 mL) |
| Weeks 5 to 8 | 1.0 mg | 10 units (0.10 mL) |
| Weeks 9 to 12 | 1.0 mg | 10 units (0.10 mL) |
Frequency: Inject once daily intramuscularly. Preclinical studies used daily IM administration for 15 to 60 days. For volumes under 10 units, 30- or 50-unit insulin syringes improve precision.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl until dissolved (do not shake).
- Label and refrigerate at 2 to 8 °C, protected from light; use within 2 weeks. At 10 mg/mL, 1 unit = 0.01 mL = 100 mcg (0.1 mg) on a U-100 insulin syringe.
Storage Instructions
Proper storage preserves peptide quality.
- Lyophilized (short-term): refrigerate at 4 °C in dry, dark conditions.
- Lyophilized (long-term): store at -20 °C for extended stability.
- Reconstituted: refrigerate at 2 to 8 °C; use within ~2 weeks; avoid freeze-thaw.
Supplies Needed
Plan based on an 8 to 16 week daily protocol.
Peptide Vials (Prostamax, 20 mg each):
- 8 weeks: ~2 vials (~40 mg total at 0.7 mg/day average).
- 12 weeks: ~3 vials (~60 mg total).
- 16 weeks: ~4 vials (~80 mg total at 1 mg/day maintenance).
Insulin Syringes (U-100):
- Per week: 7 syringes (1/day).
- 8 weeks: 56. 12 weeks: 84. 16 weeks: 112.
Bacteriostatic Water (10 mL bottles):
- 8 weeks (2 vials): 1 bottle. 12 weeks (3 vials): 1 bottle. 16 weeks (4 vials): 1 bottle.
Alcohol Swabs:
- 8 weeks: 112 (2 x 100-count). 16 weeks: 224 (3 x 100-count).
Important Notes
Practical considerations for consistency and safety.
- Use new sterile syringes or appropriate IM syringes; dispose in a sharps container.
- Rotate injection sites among large muscle groups (deltoid, vastus lateralis, gluteus).
- Inject slowly; wait a few seconds before withdrawing the needle.
- For volumes under 10 units, use 30- or 50-unit syringes for better precision.
How This Works
Prostamax (KEDP) belongs to the class of short bioregulatory peptides studied by Khavinson and colleagues. These tetrapeptides are proposed to modulate gene expression through epigenetic mechanisms, interacting with chromatin structure and histone proteins. In aged human lymphocytes, KEDP has been observed to cause pericentromeric chromatin decondensation, potentially reactivating suppressed genes. Preclinical rat models of prostatitis showed that IM administration of KEDP reduced inflammatory markers and helped prevent fibrotic changes in prostate tissue.
Benefits & Side Effects
Observations from preclinical and clinical literature.
- In rat prostatitis models, IM KEDP administration reduced inflammation and supported tissue
normalization over 15 to 60 days.
- Studies in benign prostatic hyperplasia models showed favorable effects on prostate weight and
histological parameters.
- Short bioregulatory peptides of this class generally show favorable tolerability profiles in preclinical work.
- Potential for mild injection-site reactions (redness, tenderness) as with any IM administration; rotate sites
to minimize.
- Human clinical trial data are not yet published; dosing is extrapolated from animal models.
Lifestyle Factors
Complementary strategies for best outcomes.
- Maintain a balanced diet rich in vegetables, healthy fats, and adequate protein.
- Regular physical activity supports circulation and overall metabolic health.
- Adequate hydration and limiting alcohol or caffeine may support urinary function.
- Prioritize sleep and stress management to support immune and hormonal balance.
Injection Technique
General subcutaneous guidance from clinical best-practice resources.
- Clean the vial stopper and skin with alcohol; allow to dry completely.
- For IM injection, use a 22 to 25 gauge, 1 to 1.5 inch needle inserted at 90 degrees into a large muscle (deltoid, vastus lateralis, or gluteus).
- Aspiration before IM injection is no longer routinely recommended for most sites.
- Inject slowly and steadily; wait briefly before withdrawing.
- Rotate sites systematically to avoid muscle irritation or fibrosis.
References
Source citations for further reading.
- Experimental study of Prostamax efficiency in chronic aseptic prostatitis therapy (Modern Research in Inflammation, 2013).
- Effects of short peptides on lymphocyte chromatin in senile subjects (Bulletin of Experimental Biology and Medicine, 2004).
Educational and research reference only. Not medical advice. For research use only; not for human consumption.